Giving up alcohol boosts mental wellbeing

first_imgWomen who quit alcohol may have an improved health-related quality of life, especially their mental well-being, according to a study unveiled on Monday. “More evidence suggests caution in recommending moderate drinking as part of a healthy diet,” said Michael Ni from the University of Hong Kong (HKU). The study, published in the Canadian Medical Association Journal, included 10,386 people from the FAMILY Cohort in Hong Kong who were nondrinkers or moderate drinkers between 2009 and 2013. Also Read – An income drop can harm brainModerate drinkers meant 14 drinks or less per week for men and seven drinks or less per week for women. The researchers compared their findings with data from a representative survey of 31,079 people conducted by the National Institute on Alcohol Abuse and Alcoholism in the US. The mean age of participants in the FAMILY Cohort was 49 years and 56 per cent were women. About 64 per cent of men were nondrinkers (abstainers and former drinkers) and almost 88 per cent of women were nondrinkers. Also Read – Shallu Jindal honoured with Mahatma AwardMen and women who were lifetime abstainers had the highest level of mental well-being at the start of the study (baseline). For women who were moderate drinkers and quit drinking, quitting was linked to a favourable change in mental well-being in both Chinese and American study populations. These results were apparent after adjusting for sociodemographic characteristics, body mass index, smoking status, and other factors. “Global alcohol consumption is expected to continue to increase unless effective strategies are employed,” said Ni. “Our findings suggest caution in recommendations that moderate drinking could improve health-related quality of life.”last_img read more

GPs handing out too many antibiotics harms cancer survival chances

Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily  Front Page newsletter and new  audio briefings. Antibiotics are commonly prescribed to patients undergoing traditional chemotherapy, as the treatment weakens the body, making it more vulnerable to bacterial infection.However, immunotherapy, hailed as the future of cancer drugs, relies on a lively pool of bacteria in the gut to produce friendly T Cells to take on the cancer.Dr Matthew Krebs, a consultant in experimental cancer medicine at The Christie, who co-authored the study, said: “People see their GP and the GP thinks, ‘Oh my goodness it’s a cancer patient, they need antibiotics’.“If someone genuinely has a need, then of course we should prescribe them antibiotics.“What we’re saying is think really carefully about it.”Immunotherapy drugs work by prompting the body’s immune system into recognising and fighting cancer cells.The family of treatments is currently routinely available for NHS patients suffering from forms of lung and bladder cancers and melanoma, although it is expected to become the standard treatment for many more categories of patient in the coming years.A study published in the New England Journal of Medicine in April even suggested that using immunotherapy before undergoing surgery to remove tumours significantly reduced the chances of the disease returning.However, currently only around 20 per cent of patients respond to immunotherapy and The Christie researchers, funded by Cancer Research UK, began their research because they believed antibiotics may be partly responsible for the failure.The new study, presented at the American Society of Clinical Oncology (Asco) meeting in Chicago, is the first large clinical analysis to show a definitive link. Nadina Tinsley, clinical fellow and lead author, said the greater the number and diversity of bacteria in the gut, the more T cells there are available to take on cancers, but a course of antibiotics can suppress bacteria levels for weeks.“I think potentially it’s quite a big problem,” she said. “Clearly antibiotics are a really important part of patient management and we need to treats serious infections and prevent life-threatening infection, even death.“But the challenge is striking the right balance and making sure that we identify those patients that are at risk of having a serious infection, without giving antibiotics for less justified indications and maybe overusing antibiotics.”Dr Sumanta Pal, an Asco expert and authority on immunotherapy, described the new NHS study as the “most robust” to date, adding: “It ties into a theme of really not using antibiotics for frivolous or non-indicated uses,” he said. GPs overprescribing antibiotics is significantly damaging the survival chances of cancer patients, leading oncologists have warned.A major new NHS study has found that sufferers undergoing the latest cancer treatments survived for only half as long if they were also taking the common infection-fighting drugs.Family doctors have been warned to “think really carefully”, before prescribing antibiotics after the analysis of more than 300 patients at the Christie Hospital in Manchester concluded the drugs were wiping out gut bacteria crucial for fighting cancer.The warning comes amid escalating concern that the profligate use of antibiotics by doctors has fuelled the rise of lethal drug-resistant superbugs.Researchers analysed data from 303 patients with melanoma, renal and non-small cell lung cancer being treated with immunotherapy drugs, known as checkpoint inhibitors, between 2015 and 2017.Survival rates among patients who took antibiotics – at any stage from two weeks before their cancer treatment started, to six weeks after treatment – were compared with those of patients who took none.The antibiotic group survived for an average of 317 days, while those who had not taken antibiotics survived for 651. Meanwhile those who had used antibiotics over a longer period or been given multiple types of the drug had an even lower survival span of just 193 days. read more